Terminal sterilization method with steam.

摘要

SE describes a method for sterilization TERMINAL STEAM a glass syringe or plastic PREFILLED or cartridge, said method comprising the steps of: MAINTAINING A head space in the syringe or cartridge not exceeding about 10% by volume, PROVISION at least about 2%, preferably 10%, Action time for the plunger to slide inside response to a differential pressure; AND IN THE CASE OF PLASTIC OR CARTRIDGE SYRINGE SYRINGE OR STERILIZATION cartridge into an autoclave pressure that is less than the internal pressure of the syringe or cartridge content; OR IF a glass syringe or cartridge STERILIZATION OR SYRINGE CARTRIDGE an autoclave pressure that is less than or equal or greater than the internal pressure of the syringe or cartridge content.