DERIVATIVES WITH GROUP PHENYL TRISUSTITUTED USED AS SELECTIVE INHIBITORS OF PHOSPHODIESTERASE IV.

摘要

THE COMPOUNDS OF FORMULA (I) ARE DESCRIBED, WHERE AND REPRESENTS A HALOGEN ATOM OR A GROUP -OR1 WHERE R1 IS AN OPTIONALLY SUBSTITUTED ALKYL GROUP; R2 IS AN OPTIONALLY SUBSTITUTED POLYCLOALKYL, CYCLOALKENYL, OR CYCLLOALKYL GROUP; Z IS N (R3) CO ALKYL, ARYL OR ARKYLL; R4 IS A HETEROARILO OR ARILO GROUP; X IS -O-, -S-, -CH2O -N (R5) -, WHERE R5 IS ALKYL GROUP OR HYDROGEN ATOM; N IS ZERO OR AN INTEGER OF VALUE 1,2, OR 3; AND ITS SALTS, SOLVENTS AND HYDRATES. THE COMPOUNDS ARE SELECTIVE PHOSPHODIESTERASE IV INHIBITORS AND ARE USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF INFLAMMATORY DISEASES.