IMMUNOTOXINS

摘要

A potent and specific immunotoxin is prepared bycoupling an inactivated diphtheria toxin to a binding moiety suchas a monoclonal antibody or transferrin. The immunotoxins arespecific for human tumors and leukemias and areindistinguishable in cell toxicity from that of the native toxinlinked to the binding domain without the toxicity to other cells.The immunotoxin is useful in treating graft versus host diseaseas well as selectively killing tumor cells.