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Retrovirus vectors for expression of cii-ta and activation o f hla class ii gene expression and uses thereof
Retrovirus vectors for expression of cii-ta and activation o f hla class ii gene expression and uses thereof
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机译:用于表达cii-ta和hla II类基因表达的逆转录病毒载体及其用途
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摘要
This invention provides a method to induce MHC class II gene expression in a cell capable of MHC class II gene expression which comprises transfecting the cell with a retroviral vector encoding a CII-TA protein under suitable conditions so as to express the CII-TA protein and induce MHC class II gene expression. This invention also provides a method to stimulate a specific, high-level T-cell response in a subject, or in cells, in particular, wherein the cell is a neoplastic cell or a somatic cell including, a melanocyte, a hematopoietic cell, or a stem cell.
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