Dimeric bone morphogenic proteins and fragments and analogs thereof and pharmaceutical compositions comprising them

摘要

The present invention provides synthetic peptide derivatives represented by the formula        P¹-R¹-P²wherein P¹ is a peptide having an amino acid sequence in the SEQ ID NO.:1 of the Sequence Listing, or analogues thereof; P² is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R¹ denotes a linker with a property that does not interfere with the activity of the each peptide P¹ and P² to bind N-terminal end of the peptides P¹ and P².;The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier.;The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof.