Indole Derivatives as CCK Receptor Antagonists as CCK Receptor Antagonists

摘要

The present invention describes novel cholestyocyte antagonists of formula (I) which are useful as obesity agents, gastric hyperplasia in gastrointestinal tracts, therapeutic agents for gastrin-dependent tumors or therapeutic agents for psychosis and having excellent bioavailability. In addition, the compound is an anxiolytic and an anti-ulcer agent. Nicotine, diazepam, alcohol, cocaine, coffee or an opioid (opioid). The compounds of the present invention are also useful for treating and / or preventing panic attacks. Pharmaceutical compositions and methods of making the same are also described. An important characteristic of the present invention is the absolute oral bioavailability of the compound.