BENZODIAZEPIN DERIVATIVES USEFUL AS CCK-RECEPTOR ANTAGONISTS USEFUL AS A CCK-RECEPTOR ANTAGONIST

摘要

The present invention relates to a benzodiazepine derivative represented by the following structural formula (I) or a pharmaceutically acceptable salt thereof. These compounds are gastrin and / or CCK-B receptor antagonists.;Wherein (a) R RTI ID = 0.0 ^One-CH₂CHOH (CH₂) aR⁴Or a ketone group-CH₂CO (CH₂) aR⁵(Wherein a is 0 or 1, R⁴And R⁵Is selected from an alkyl group, a cycloalkyl group, a saturated heteroring group optionally substituted on a heteroatom; (b) R²And R³Are each selected from an aromatic carbon ring group and a hetero ring group; (c) W and X are each selected from an alkyl group, an alkoxy group, a halogen atom and a hydrogen atom.