Preparation for the production of hepatitis B virus surface antigen and polymerized human serum albumin receptor-bearing particle-containing vaccines, animal cells for the production of these particles and methods for their maintenance

摘要

Composition useful for producing vaccines containing particles having immunogenic properties characteristic of antigen HBsAg, said particles being more particularly characterized in that they also contain a receptor for polymerized human albumin. They are obtained by transformation of human or animal cells by a vector containing a DNA sequence coding for the S and pre-S regions of a gene of viral hepatitis B, said DNA sequence being placed under direct control of a promoter enabling the efficient transcription of said sequence in human or animal cells transformable by said vector.