COMPOSITION USEFUL FOR THE PRODUCTION OF VACCINES CONTAINING PARTICLES WITH THE SURFACE ANTIGEN OF THE HEPATITIS B VIRUS AND THE RECEPTOR OF THE POLYMERIZED HUMAN SERUM ALBUMIN, ANIMAL CELLS CAPABLE OF PRODUCING SUCH PARTICLES AND PROCESS FOR THEIR OBTENTION

摘要

composition useful for the manufacture of tale-nant vaccinia particles carry the virus surface antigens of the hepatitis B and the receptor for polymerized human albumin America-se, animal cells capable of producing such particles and process for their ob-tantion. SHORT The invention relates to a composition useful for the manufacture of vaccines containing particles having the immunogenic properties characteristic of an-tigène HB Ag, these particles are particularly characterized by the fact that said particles also con-held receiver for polymerized human albumin. They are obtained by transformation of human or animal cells with a vector containing a DNA sequence coding for the regions 5 and 5 a pre-genome of the viral hepatitis B, said DNA sequence being under the direct control of a per-putting the efficient transcription promoter of said sequence in the human or animal cells transformable by said vector. (No picture)