COMPOSITION USEFUL FOR THE MANUFACTURE OF VACCINES CONTAINING PARTICLES CARRYING THE HEPATITIS B VIRUS SURFACE ANTIGEN AND THE HUMAN POLYMERIZED SERUM ALBUMIN RECEPTOR, ANIMAL CELLS CAPABLE OF PRODUCING SUCH PARTICLES AND METHOD FOR THEIR PREPARATION

摘要

The invention relates to a composition useful for the manufacture of vaccinates containing particles having the characteristic immunological properties of the HBSag antigen, these particles being more particularly characterized by the fact that said particles also contain a receptor for human albumin. POLYMERIZED. THEY ARE OBTAINED BY TRANSFORMATION OF HUMAN OR ANIMAL CELLS BY A VECTOR CONTAINING A DNA SEQUENCE ENCODING FOR THE REGIONS S AND PRE-S OF A GENOME OF VIRAL HEPATITIS B, THIS DNA SEQUENCE BEING PLACED UNDER DIRECT CONTROL A PROMOTER FOR EFFICIENT TRANSCRIPTION OF SAID SEQUENCE IN HUMAN OR ANIMAL CELLS TRANSFORMABLE BY SAID VECTOR. / P