The invention relates to combinations of atovaquone and rifabutin, their use in the treatment and prophylaxis of infections caused by P.carinii and their use in the manufacture of medicaments for the treatment and/or prophylaxis of such infections. The combinations can conveniently be administered in a single pharmaceutical formulation. Preferably, atovaquone and rifabutin are administered in a potentiating ratio so that they act in synergy.
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