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The acetic acid derivatives of 3-amino-2-oxo-1-piperidine arginine mimetics as enzyme inhibitors
The acetic acid derivatives of 3-amino-2-oxo-1-piperidine arginine mimetics as enzyme inhibitors
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机译:3-氨基-2-氧代-1-哌啶精氨酸模拟物的乙酸衍生物作为酶抑制剂
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摘要
The present invention discloses peptide aldehydes having a lactam group as part of the peptide backbone and having an original mimic group such as an amidinopiperidine or amidinophengyl tail. These compounds are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
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