jihuenirumechiruamin derivative

摘要

NEW MATERIAL:The compound of formula I (R1 is H, lower alkyl, formyl, lower alkylcarbonyl, lower alkoxycarbonyl, etc.; R2 is H, halogen, lower alkyl, lower alkoxy, OH, nitro, etc.) or its salt. EXAMPLE:(3,5-Di-t-butyl-4-hydroxyphenyl)phenylmethylamine. USE:The compound has strong anti-inflammatory action and lipoxygenase and/or cyclooxygenase-inhibiting action and extremely weak action to induce digestive organ disorder. It is especially useful as a new-type anti-inflammatory, analgesic and anti-rheumatic agent. PREPARATION:A compound of formula I (R1 is H) is produced by hydrogenating a diphenylmethylimine derivative of formula II in the presence of a platinum catalyst and preferably an organic acid such as acetic acid or by reducing the compound with zinc-acetic acid, tin-hydrochloric acid, etc.