首页> 外国专利> Compounded pharmaceutical composition and processes to treat immune deficiencies or to control cancer growth and to increase the number of cytotoxic t lymphocytes in mammals

Compounded pharmaceutical composition and processes to treat immune deficiencies or to control cancer growth and to increase the number of cytotoxic t lymphocytes in mammals

机译:用于治疗免疫缺陷或控制癌症生长并增加哺乳动物细胞毒性t淋巴细胞数量的复合药物组合物和方法

摘要

The present invention comprises a compound of formula I: R1 of Formula I is substituted amino represented by formula NR5R6 wherein R5 and R6 are independently selected from the group consisting of hydrogen, C1-4 alkyl, and unsubstituted amino with the proviso that R5 and R6 are not both hydrogen, and further that R5 and R6 are not both amino. R2 and R3 of Formula I are independently selected from the group consisting of hydrogen; C1-4 alkyl; amino; substituted or unsubstituted thiol; and halogen. Moreover, R4 of Formula I is represented by the formula R12-X12 wherein R12 is a saturated or unsaturated linear hydrocarbon chain of 5-20 carbons optionally containing one or more interruptions within the chain by a heteroatom, and optionally substituted with one or more =O, or =S. Finally, X12 is selected from the group consisting of hydroxy, an aminoalkyl group, and a known amino acid bound by its alpha -amino group.
机译:本发明包括式I的化合物:式I的R 1是由式NR 5 R 6表示的取代的氨基,其中R 5和R 6独立地选自氢,C 1-4烷基和未取代的氨基,条件是R 5和R 6 R 5和R 6都不都是氢。式I的R 2和R 3独立地选自氢; C 1-4烷基;氨基取代或未取代的硫醇;和卤素。此外,式I的R4由式R12-X12表示,其中R12是5-20个碳的饱和或不饱和直链烃链,其在链中任选地包含一个或多个杂原子,并且任选地被一个或多个=取代。 O,或= S。最后,X12选自羟基,氨基烷基和通过其α-氨基结合的已知氨基酸。

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