compound; use of a compound; pharmaceutical composition for selectively inhibiting peripheral fatty acid amide hydrolase (faah); pharmaceutical composition for treating a selected condition of pain, inflammation and an immune disorder; method of treating pain and / or inflammation; method for treating a condition selected from the group consisting of pain, inflammation and an immune disorder; method for increasing in a mammal in need of the same peripheral levels of anandamide, oleoylethanolamide (oea), palmitylethanolamide (pea) or stearoethylethanolamide (sea); pharmaceutical composition and method for treating a selected condition of dermatitis, mucositis or overreactivity of peripheral sensory neurons, neurodermatitis, overactive bladder or cough

摘要

The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit.