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USE OF GLYCINE, PRECURSORS AND SALTS THEREOF FOR PREPARING A MEDICAMENT OR A NUTRIENT FORMULATION FOR REDUCING TNF LEVELS AND THE MEDICAMENT CONTAINING SUCH AMINO ACIDS
USE OF GLYCINE, PRECURSORS AND SALTS THEREOF FOR PREPARING A MEDICAMENT OR A NUTRIENT FORMULATION FOR REDUCING TNF LEVELS AND THE MEDICAMENT CONTAINING SUCH AMINO ACIDS
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机译:使用甘氨酸,前体和盐制备药物或营养制剂以降低TNF水平和含有这种氨基酸的药物
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摘要
The invention provides the use of at least one amino acid selected from the group consisting of glycine, alanine and serine, or the physiologically acceptable salts thereof, in the preparation of a medicament or nutritional formulation for the diminution of tumor necrosis factor (TNF) levels in patients in whom said levels are elevated beyond those which mediate physiological homeostasis and local inflammation. Such diminution of TNF levels can i.a. be achieved by inhibition or diminution of: (i) tumor necrosis factor (TNF) production by macrophage-type cells; (ii) the release of TNF from macrophage-type cells; and/or (iii) the binding of TNF by TNF receptors.
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