The present invention relates to a region specific process for the preparation of a cis-amine-2-indane mixture of any of its enantiomeric or enantiomeric mixtures, the method of which is the chemical retention chemical integrity of a carbon-oxygen bond at the C-2 position of the grapevine-denexide. the process comprises: (a) leaching 1 equivalent of indene oxide in a brewing agent and in admixture of a given case, from which an alkyl nitrile or aryl nitrile is used as the coolant; (b) the lime vapor is about 2 equivalents of acid equivalents, a strong acidic acid or Lewis acid or organic acid is used as the acid, and the temperature of the mixture is maintained at -7070C to + 30řC for a period of 0.25 to 6.0 hours; and (c) adding excess water to the mixture and hydrolyzing it for 0.5 to 8.0 hours at 25-100 ° C to give the enantiomer or enantiomer mixture of the cis-1-amine-2-indane. ŕ
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