FORM III CRYSTALLINE (R-(R*,R*)-2-(4-FLUOROPHENYL)-BETA-DELTA-DIHYDROXY-5-(1-METH YL-ETHYL)-3-PHENYL-4-((PHENYLAMINO)CARBONYL)-1H-PYRROLE-1-HE PTANOIC ACID HEMI CALCIUM SALT (ATORVASTATIN)

摘要

A novel crystalline form of [R-(R*,R*)]-2-(4-fluorophenyl)-'beta','delta'-dihydroxy-5-(1 -methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole- 1-heptanoic acid hemi calcium salt designated Form III is characterized by its X-ray powder diffraction and/or solid state NMR is described, as well as methods for the preparation and pharmaceutical composition of the same, which is useful as an agent for treating hyperlipidemia and hypercholesterolemia.