PROSES UNTUK PEMBUATAN CHIRAL ALKOHOL TAK JENUH DENGAN KEMURNIAN YANG TINGGI

摘要

The catalytic asymmetric hydrogenation of enol esters with a vinyllic or acetylenic substituent proceeds with extremely high enantioselectivity using a Rhodium-chiral bisphosphine catalyst. This is at variance with the hydrogenation of enol esters bearing a saturated substituent, which are hydrogenated with only marginal enantioselectivity under the same conditions.