USE OF A PANEL OF HETEROKARYONS TO PRODUCE VARIANTS OF MULTIMERIC PROTEINS

摘要

The present invention provides methods and compositions for producing andscreening combinatorial libraries of multimeric proteins. The presentinvention relies on the use of filamentous fungal heterokaryons that areproduced using two or more parent strains into which a population of DNAmolecules encoding variants of a multimeric protein have been introduced.