Methods and compositions for producing and screening combinatorial based libraries of multimeric proteins using filamentous fungal heterokaryons multimeric molecules

摘要

The application provides methods, compositions, panels and a kit containing the panels, for producing and screening combinatorial libraries of multimeric proteins. The panels made rely on the use of filamentous fungal heterokaryons that are produced using two or more parent strains into which a population of DNA molecules encoding variants of a multimeric protein have been introduced.