Use of substance p antagonists for treating social phobia

摘要

The invention relates to the use of a compound of formula (I) or of a pharmaceutically utilizable salt thereof, in which R1 is an unsubstituted or substituted aralkyl, aryloxyalkyl, heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl radical or the acyl radical of an alpha -amino acid which is unsubstituted or N-substituted by lower alkanoyl or carbamoyl-lower-alkanoyl; R2 is cycloalkyl or an unsubstituted or substituted aryl or heteroaryl radical; R3 is hydrogen, alkyl, carbamoyl or an alkanoyl or alkenoyl radical which is unsubstituted or substituted by carboxyl or esterified or amidated carboxyl; R4 is an unsubstituted or substituted aryl or unhydrogenated or partially hydrogenated heteroaryl radical; X1 is methylene, ethylene, a direct linkage, a carbonyl group which may be ketalized, or an unetherified or etherified hydroxymethylene group; X2 is alkylene, carbonyl or a direct linkage; and X3 is carbonyl, oxo-lower-alkylene, oxo(aza)-lower-alkylene or an alkylene radical which is unsubstituted or substituted by phenyl, hydroxymethyl, carboxyl which may be esterified or amidated, or by hydroxyl in a position higher than alpha ; for producing pharmaceutical products for the treatment of social phobia.