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Mouse lacking heart-muscle adenine nucleotide translocator protein and methods
Mouse lacking heart-muscle adenine nucleotide translocator protein and methods
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机译:缺少心脏肌肉腺嘌呤核苷酸转运蛋白的小鼠和方法
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摘要
Provided are transgenic mice genetically engineered for a deficiency of the heart-skeletal muscle isoform of the adenine nucleotide translocator protein (Ant1). These mice exhibit histological, biochemical and physiological signs of deficiency in oxidative phosphorylation and energy generation, and these mice provide the first animal model for mitochondrial myopathy and hypertrophic cardiomyopathy. This animal model is used in methods for testing compounds for therapeutic value in treating failure to exchange ATP and ADP across the mitochondrial inner membrane, OXPHOS deficiency and in treating cardiac hypertrophy.
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