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TRANSGENIC NON-HUMAN MAMMAL EXPRESSING FLAG-APP-C100 FUSION PROTEIN
TRANSGENIC NON-HUMAN MAMMAL EXPRESSING FLAG-APP-C100 FUSION PROTEIN
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机译:转基因非人类表达FLAG-APP-C100融合蛋白
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摘要
Disclosed is a transgenic non-human mammal that expresses in its brain a transgene encoding an APP-C100 polypeptide with the flag amino acid sequence fused to the amino terminus of the APP-C100. This transgenic non-human mammal is an improved in vivo model for Alzheimer's disease-like neuropathology and associated cognitive impairment. The improvement includes accelerated development of AD-like neuropathology and cognitive impairment. The AD-like neurodegeneration and associated cognitive impairment in mice produced according to this invention appear at least six months sooner than they appear in APP-C100-expressing transgenic mice.
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