Intermediate compounds for preparing endothelin-receptor antagonist triterpene derivatives

摘要

Triterpene derivatives of the formula (I): CHEM wherein R1 is hydrogen or metabolic ester residue; and R2 is hydrogen or -R3-R4 wherein R3 is -SO3-, -CH2COO-, -COCOO-, or -COR5COO- (R5 is lower alkylene or lower alkenylene), and R4 is hydrogen or metabolic ester residue, or pharmaceutically acceptable salts thereof, have anti-endothelin activities and are useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin.