DERIVATIVES OF CIS-DIAMMINEDIIMIDAZOLYL PLATINUM DICHLORIDE SHOWING ANTIPROLIFERATIVE ACTIVITY AND A METHOD OF THEIR SYNTHESIS

摘要

FIELD: organometallic compounds. SUBSTANCE: invention proposes the use of derivatives of cis-diamminediimidazolyl platinum dichloride of the general formula given in description. Method of synthesis involves interaction of cis-diimidazole platinum dichloride with 25% ammonium an aqueous solution at heating and intensive stirring up to complete dissolving followed by cooling and isolation of the end product. Synthesized compound shows antiproliferative and cytostatic activity and can be used in medicine, pharmaceutical and chemical industry. EFFECT: improved method of synthesis, enhanced effectiveness of compound. 2 cl, 5 tbl