METHOD OF PREPARING 7-BROMO-1,3-DIHYDRO-5-2- CHLOROPHENYL-2H-1,4-BENZDIAZEPIN-2-ONE, 5-BROMO-2-2- CHLOROACETAMIDO-2amp;prime;-CLOROBENZOPHENONE

摘要

FIELD: chemical industry. SUBSTANCE: present invention describes novel method of preparing 7-bromo-1,3-dihydro-5-(2- chlorophenyl)-2H-1,4-benzdiazepin-2-one (I) by reacting aminobenzophenone with monochloroacetic chloride, subsequently treating the resulting 5-bromo-2′-chloro- (2-chloroacetamido) benzophenone (II) with alkali metal iodide to obtain 5-bromo-2-(2-iodoacetamido)-2′- chlorobenzophenone of formula III. Compound III is treated with ammonia, and the resulting 2-(2- aminoacetamido)-5-bromo-2′-chlorobenzophenone is cyclized. EFFECT: high yield and high purity of the desired product. 3 cl, 4 ex