The invention features a novel adenovirus vector for minimising the problem of formation of viral particles capable of replication during its propagation in a complementation cell. It is characterised in that at least part of the sequences equally present in the complementation cell is located in a site different from the natural position in the parental adenovirus genome. It also features a host cell and an infectious viral particle containing said vector. Finally, it features a pharmaceutical composition containing same and the therapeutic use thereof.
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