Method for controlling and/or lowering serum glucose and fatty acid concentrations and hypertensive blood pressure in non-insulin- dependent diabetic patients

摘要

The present invention is a method of treating non-insulin- dependent diabetes mellitus comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula (I) for a period of time of more than 6 days: ##STR1## wherein Y is OP PR is OH, NHCONR.sup.4 R.sup.5, or N═C(NR.sup. 4 R. sup.5).sub. 2 ;PPR.sup.4 and R.sup.5 are each independently selected from the group consisting of hydrogen; C.sub.1-10 alkyl, straight or branched chain; aryl C.sub.1-14 alkyl; and mono- or disubstituted aryl C. sub.1-4 alkyl where the substituents are fluoro, chloro, bromo, iodo or C. sub.1-10 alkyl, straight or branched chain; R. sup.1 and R.sup.2 are each independent selected from the group consisting of hydrogen, amino, and mono- or di-substituted amino where the substituents are C.sub.1-10 alkyl, straight or branched chain C.sub.3-8, cycloalkyl; provided that R. sup.1 and R.sup.2 may not both be amino or substituted amino; and R.sup. 3 is hydrogen, trifluoromethyl; fluoro; chloro; bromo; or iodo; or a pharmaceutically acceptable salt thereof.