Production manner of the sulfonic acid ester of N aryl methyl - ethanolamine as a 1,4,7,10 tetoraazashikurododekan derivative, and the intermediate field which are obtained from the N aryl methyl - aziridine derivative and the aforementioned derivative

摘要

(57) Abstract As for the aziridine receiving the annular oligomer conversion reaction, when preparing the chelation medicine in order to use for example as the contrast material of image diagnostics the usefulness, it is possible to generate poriazashikuroarukan chemical compound. Especially, when N-benjiru-ajirijin converts, annular four quantitative embody and the deviation from to benzyl preparing the chelation medicine it is useful as generates shikuren which is the intermediate field. This invention, formula (i) (however, as for R₁, independently, to be hydrogen or Ar, as for Ar it is phenyl group displacement with option.)It shows, N-benjiru-ajirijin and other N-ariru methyl - the aziridine it is something which offers especially the attractive root in order to produce, this production manner the N-ariru methyl which was refined - includes the fact that it reacts the sulfonic acid ester of ethanolamine with the base. The N-ariru methyl which is the intermediate field - the sulfonic acid ester of ethanolamine is displayed with the formula, R''NHCH₂ CH₂ OSO₃ H, it is the aryl methyl group R''ga N- (bis aryl methyl) basis or the N- (triallyl methyl) basis of Order n. In addition, another edge strip of this invention is something which offers the chemical compound formula (ii). However, as for Ar and R₁ when it defined first, it is similar, the ArCHR₁ section where two differs at least exists.