CHEMOSYNTHESIS OF CYCLIC LIPOPEPTIDE COMPOUND AND CYCLIC LIPOPEPTIDE

摘要

PROBLEM TO BE SOLVED: To efficiently synthesize the subject compound by binding an amino acid, etc., having plural functional groups bound to lipids to a carrier, carrying out a chain-extending reaction by the second functional group, cyclizing the third functional group of the starting material with the terminal group, and separating the carrier therefrom. ;SOLUTION: This chemosynthetic method for a cyclic lipopeptide compound comprises the step of forming a carrier-bound body by binding the first functional group F_1a of a starting material of an amino acid A₁ or a compound having two or more functional groups binding to lipid components and the amino acid A₁ to a carrier, the step of carrying out successive extension reaction of amino acids at the part of the second functional group F_1b of the carrier- bound starting material, and joining one or more 3-functional amino acid to the reaction when the starting material has only two functional groups, the step of cyclizing the extended reaction product by binding the functional group F_n of the growing end amino acid A_n of the extended reaction product to the third functional group F_1c of the starting material or the third functional group F_x of the amino acid residue A_x and the step of separating the obtained cyclic compound from the carrier and further binding a lipid component to the obtained cyclic product if the cyclic product having no lipid component bound thereto to provide the objective cyclic lipopeptide compound.;COPYRIGHT: (C)1998,JPO