Derivatives of 4 - (1h-benzimidazol-2-yl) 1,4 diazepanos replaced useful for the treatment of allergic diseases, Pharmaceutical Composition and uses in the production of drugs.

摘要

Described are compounds of the formula (i), where M is 2 or 3; n is 0 OR 1; Q is 1 or 2; R is 0 OR 1; G1 is or - CH2 - C (o) - G2 - CH2 -,;- ch (CH3) - or - C (o) - G3 is - CH2 - or - C (o) -; AR1 is a radical selected from the group consisting of ustituido phenyl, naphthyl substituted phenyl, naphthyl, piridilo,,Piridilosustituido and tienilo; ar2 is a radical selected from substituted phenyl, substituted phenyl, metilendioxofenilo, metilendioxofenilo,Etilendioxofeniloy etilendioxofenilosustituido; R 4 is 1 to 3 substituents each independently selected from the group consisting of hydrogen, halogen, - CF3,C1 - C6 alkyl and alkoxy C1 - C6; R5 is selected from the group consisting of hydrogen, alquiloc1 - C4 - (CH2) W - O - (CH2) tco2r8 JCN, - (CH2), - (CH2) or - (CH2) co2r6, nr16r17, UC (o) - (CH2) UC (o) CH3 (CH2), Par3,- (CH2) or W - - - ch2ch chcf3 R7, =, - (CH2) 2ch = CH2 = CH2, ch2ch -, - ch2ch chch3 chch2ch3 ch2ch = =, -, - ch2ch = C (CH3 (CH2) 2 and (OR) kr9, GS)Where W is a numeroentero 2 to 5; t is an integer from 1 to 3; J is an integer from 1 to 5; or is a whole Number 1 to 5: P is an integer from 1 to 4; G Is 2 or 3; K is 0,1 or 2; R8 is Hydrogen or c1-c4 alkyl; R4 is Hydrogen or c1-c4 alkyl; eshidrogeno oalquilo c1-c4 R16, R17 is Hydrogen or c1-c4 alkyl; R19 is c1-c4 alkyl or phenyl radical is a radical AR3.Selected from the group consisting enfenilo, substituted phenyl, substituted piridilo, piridilo, furilo, furilosustituido, imidazoles, I midazoles replaced, tienilo, tienilo replaced,Substituted triazoles and tetrazoles, triazoles and tetrazoles replaced; provided that if G1 is a - C (o) -, then G2 - CH2 - or - ch (CH3) - and - CH2 - G3; provided that, when G2 is -, - C (o)Then G1 and G3 - CH2 - CH2 - Always; also, when G3 - C (o) -, then G1 - and G2 - CH2 - CH2 -