Method for Preparation of Enantiomers of demetiltramadol or -

摘要

In the preparation procedure (I) of O-Demethytramatrado, a racemate of tramadol is used as its base; L- (+) -Tartarico precipitates the anorexic isomer of tramadol through L-, After the release of Laba, the enantiomer (-) i-o-demethyltramatadol of isobutyl aluminum is formed by hydrogenation of diisobutyl aluminum; in the water area as the source of Tarico settlement, Deo demethyltramado prepares the enantiomer (+) Deo demethyltramado, leaves the base of Tramado enliber TAD, and reacts with the hydrodiisobutyl aluminum. The enantiomers of o-demethyltramitrado can be used as analgesics.