Method for Preparation of Enantiomers of or - demetiltramadol and its application in Medicine

摘要

Characterized in that it comprises: (a) make base salt (Racemic tramadol tramadol hydrochloride); (b) to precipitate by L (+) - Tartaric acid and an alcohol in the presence of C1 - C5The enantiomer (-) of tramadol; c) release the basis; (d) convert the corresponding enantiomer of the basis of tramadol tramadol hydrochloride,From which then allows the basis; (e) REACT with the base HYDRIDE di Isobutyl AluminiumIn the presence of toluene; in the step (b) of precipitation Mother Liquor with l (+) - Tartaric acid, prepares the enantiomer (+), following the steps (c), (d) and (e).This procedure allows to obtain Pure Enantiomers of or - demetiltramadol, with high performance, to be used as an Analgesic in base form and / or Salt as a racemate or enantiomer (+),As the only active substance or in combination with tramadol