A process for the preparation of compounds derived from 2.5 - is - 4 - hydroxy - azahexano; Intermediate imino Hydrazone and Nitrile, Nitrile, and processes to prepare such Intermediates.And imino Hydrazone

摘要

Describes a process for the preparation of compounds derived from 2.5 - [] - 4 - hydroxy azahexano diamine of formula (i),Where R1 is Hydrogen or a grupoamino protector suitable alkyl; R2 is replaced or not replaced; R3 is Hydrogen, alkyl, aryl, heterociclilo, replaced or not replaced,Ocicloalquil replaced or not replaced regardless of R1, R4,Amino Group is a hydrogen or adequate Protective and M is a number from 1 to 7 may be present; and where other Protecting groups suitable for functional groupsWhich compounds are active substances can antiviralmente or pharmaceutically Active emplearsecomo initial Compounds, in particular the antivirals.The precursor is a compound oxoThat in turn espreparado by hydrogenation with HYDRIDE or a suitable Compound with Hydrogen in the presence of a suitable Catalyst and Migration from an acyl Hydrazone toTime is preferably a nitrilovia imino Compound by means of hydrogenation reaction with Hydrazine and derivadode which is prepared by reaction of an aldehyde with a DriftOJ Reagent of a carboxylic acid in the presence of a Salt of cyanide; compuestosintermedios required for this; and processes for preparing such Intermediates.