Retroviral vectors for the treatment of tumors and cell lines containing them

摘要

PCT No. PCT/FR93/01259 Sec. 371 Date Oct. 11, 1995 Sec. 102(e) Date Oct. 11, 1995 PCT Filed Dec. 16, 1993 PCT Pub. No. WO94/13824 PCT Pub. Date Jul. 23, 1994The invention relates to recombinant retroviral vectors, derived from Moloney MuLV, carrying a suicide gene susceptible of transforming an inactive substance into a toxic substance for cells going through a division process, said vectors being characterized by the presence in their structure of LTR sequences from variants of MuLV, and having the properties: (a) of not being inactivated during passage through the carcino-embryonic or line germinal cells of mice; (b) the expression of the suicide gene kills only the cells in the course of division.