DERIVATIVES OF BENZIL (IDEIN) -LACTAMS, THEIR OBTAINING AND APPLICATION AS A SELECTIVE (ANT) AGONISTS OF 5-HT1A AND / OR 5-HT1D RECEPTORS

摘要

The compound of formula (I), where R represents a group of formula G, G, G, G or G; R5 is hydrogen, (C-C) alkyl, phenyl or naphthyl, where said phenyl or naphthyl may optionally be substituted with one or more substituents, preferably substituents from 0 to 3, independently selected from chloro, fluoro, bromo, iodo, (C-C) alkyl, (C-C) alkoxy, trifluoromethyl, cyano and SO (C-C) alkyl, where g is 0, 1 or 2; R 6 is (CH) B, where m is 0, 1, 2, or 3, and B is hydrogen, phenyl, naphthyl, or a 5- or 6-membered heteroaryl group containing from one to four heteroatoms in the ring (for example, furyl, thienyl , pyridyl, pyrimidyl, thiazolyl, pyrazolyl, isothiazolyl, oxazolyl, isooxazolyl, pyrrolyl, triazolyl, tetrazolyl, imidazolyl, etc.), and each of the above aryl and heteroaryl groups may be optionally substituted by one or more substituents, preferably substituents a number from 0 to 3, independently selected from x opo, fluoro, bromo, iodo, (C-C) alkyl, (C-C) alkoxy, trifluoromethyl, cyano, hydroxy, COOH and SO (C.-C) alkyl, wherein g is 0, 1 or 2; Z is CRR, where R and R are independently selected from hydrogen, (C — C) alkyl and trifluoromethyl, or Z may be one of the aryl or heteroaryl groups mentioned above in Definition B, where the two adjacent members of the ring Z are also members of Ring A; X represents hydrogen, chloro, fluoro, bromo, iodo, cyano, (C-C) alkyl, hydroxy, trifluoromethyl, (C-C) alkoxy, SO (C-C) alkyl, where g is 0, 1 or 2, COR or CONRR, each of R, R and R is independently selected from the radicals mentioned earlier in the definition of R; or R and R together with the nitrogen to which they are attached, form a ring containing from 5 to 7 members, which may contain from 0 to 4 heteroatoms selected from nitrogen, sulfur and oxygen; n is 0, 1, 2, 3 or 4, and