BENKYL (IDENE) LACTAM DERIVATIVES, THEIR PREPARATION AND USE AS SELECTIVE (ANT) AGONISTS OF 5-HT1A AND / OR 5-HT1D RECEPTORS

摘要

The present invention relates to lactam derivatives of the formulawherein R1, R2, R3, A, X, Z, n and the dashed line are defined herein, and pharmaceutical compositions thereof, to processes and intermediates for their preparation, and to their medicinal use as selective agonists and antagonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1A and 5-HT1D receptors. These compounds are useful in treating or preventing migraine, depression and other disorders for which a 5-HT1 agonist or antagonist is indicated.