首页> 外国专利> PIPERIDINE CARBOXYLIC ACID DERIVATIVES AS ROTAMASE ENZYME ACTIVITY INHIBITORS AND USE OF THEM FOR PRODUCING PHARMACEUTICAL COMPOSITIONS SUITABLE FOR TREATING NEUROLOGICAL ACTIVITY

PIPERIDINE CARBOXYLIC ACID DERIVATIVES AS ROTAMASE ENZYME ACTIVITY INHIBITORS AND USE OF THEM FOR PRODUCING PHARMACEUTICAL COMPOSITIONS SUITABLE FOR TREATING NEUROLOGICAL ACTIVITY

机译:哌啶羧酸衍生物作为旋转酶活性抑制剂,并用于生产适于治疗神经活性的药物组合物

摘要

FIELD OF THE INVENTION The present invention relates to the use of (I) the use of general-purpose papillae pepperic acid derivatives for the production of an antiproliferative protein for binding enzyme activity and, in particular, for the production of peptidylprilyl excitatory or potassium enzyme activity inhibitors, for the stimulation or stimulation or enhancement of nerve growth. In general formula (I), A is -CH 2 -, -O-, = NH- or = N-alkyl; B and D independently represent, inter alia, Ar-ring, alkyl, cycloalkyl, or cycloalkenyl, or (a) a tubular ring of the formula wherein Q is hydrogen, alkyl or alkenyl; T is Ar-ring or ring-tube; The term "hydrogen" or "-O-alkyl", "-O-alkenyl", "alkyl", "alkenyl", "cycloalkyl" or "cycloalkenyl", or "Ar-ring", denotes a hydrogen atom, alkyl or benzyl tube; K is alkyl, benzyl or cyclohexylmethyl-methyl; or J and K together form a 5- to 7-membered ring cyclic ring. (I) (a)
机译:发明领域本发明涉及以下用途:(I)通用乳头状胡椒酸衍生物用于产生用于结合酶活性的抗增殖蛋白的用途,特别是用于肽基prilyl兴奋性或钾酶的用途。活性抑制剂,用于刺激或刺激或增强神经生长。通式(I)中,A为-CH 2-,-O-,= NH-或= N-烷基。 B和D特别地独立地代表Ar-环,烷基,环烷基或环烯基,或(a)下式的管状环,其中Q是氢,烷基或烯基; T是Ar环或环管;术语“氢”或“ -O-烷基”,“-O-烯基”,“烷基”,“烯基”,“环烷基”或“环烯基”或“ Ar-环”表示氢原子,烷基或苄基管; K为烷基,苄基或环己基甲基-甲基;或J和K一起形成5至7元环环。 (一)(一)

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