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LIVE VACCINES AGAINST GRAM-NEGATIVE PATHOGENS, EXPRESSING HETEROLOGOUS O-ANTIGENS.
LIVE VACCINES AGAINST GRAM-NEGATIVE PATHOGENS, EXPRESSING HETEROLOGOUS O-ANTIGENS.
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机译:对抗革兰氏阴性病原体的活疫苗,表达异源O型抗原。
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摘要
The present invention relates to live attenuated gram-negative vaccine carrier strains which are useful for expression and delivery of heterologous O-antigens (O-PS) from gram-negative pathogens. Said strains are deficient in the expression of homologous O-PS due to a defined genetic modification, preferably a deletion, and, thus, capable of efficiently expressing a desired heterologous O-PS in such a way that it is covalently coupled either to homologous or heterologous LPS core lipid A. The present invention furthermore relates to live vaccine carrier strains containing a heterologous gene or a set of heterologous genes encoding O-PS. Preferably, said strains additionally contain genes necessary for the synthesis of complete smooth heterologous LPS. The present invention also relates to live vaccines comprising said strains, preferably for immunization against gram-negative enteric pathogens.
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