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HYBRIDOMA amp; METHOD OF PREPARING A MONOCLONAL ANTIBODY REACTIVE WITH HC GP-39, USE amp; TREATMENT OF RHEUMATOID ARTHRITIS
HYBRIDOMA amp; METHOD OF PREPARING A MONOCLONAL ANTIBODY REACTIVE WITH HC GP-39, USE amp; TREATMENT OF RHEUMATOID ARTHRITIS
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机译:HC GP-39单克隆抗体抗体的制备及用途,类风湿关节炎的使用与治疗
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摘要
The present invention relates to an efficient method of producing monoclonal antibodies against surface antigens of cells and viruses. The method accommodates for antigens which are present in only relatively small amounts, or antigens of which only very small amounts are available or antigens which easily lose their in vivo conformation. Thus the method according to the invention comprises a series of steps, comprising a step in which B-cells from a mammal injected with surface antigen-comprising material are enriched with respect to the relative number of specific B-cells and a step which comprises a small-scale fusion technique.
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