METHODS OF AND COMPOSITIONS FOR EFFECTING SYNTHESIS OF DIOXOLANIC NUCLEOSIDES OF BETA CONFIGURATION

摘要

The present invention relates to methods and intermediates for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10 DEG C. wherein R1 and L are as defined in the specification.