首页> 外国专利> Antifungal composition containing (2R CIS) - 4 - 4 - 4 - 5 - (2,4-difluorophenyl) - tetrahydro - (1H - 1,2, 54 - triazol 1 - ylmethyl) furan-3 - il methoxy phenyl - 1-piperazinyl phenyl 2 - dihydro - 4 - 2 - (S) - 1 - (S) - ethyl - 2 - hydroxypropyl - 3h 1,2,4 - triazole - 3-one

Antifungal composition containing (2R CIS) - 4 - 4 - 4 - 5 - (2,4-difluorophenyl) - tetrahydro - (1H - 1,2, 54 - triazol 1 - ylmethyl) furan-3 - il methoxy phenyl - 1-piperazinyl phenyl 2 - dihydro - 4 - 2 - (S) - 1 - (S) - ethyl - 2 - hydroxypropyl - 3h 1,2,4 - triazole - 3-one

机译:包含(2R CIS)-4-[4-[[4-[[5-(2,4-二氟苯基)-四氢-(1H-1,2,54-三唑1-基甲基)]呋喃3-il的抗真菌组合物] [甲氧基]苯基]-1-哌嗪基]苯基] 2-二氢-4-2-[(S)-1-(S)-乙基-2-羟丙基-3h 1,2,4-三唑-3-one

摘要

A Pharmaceutical composition comprising: i) an anti Yeast agent which is (-) - (2R CIS) - 4 - [4 - [[4 - [[5 - (2,4-difluorophenyl) - 5 - (1H - trahidro - 1.2.4 - triazol 1 - ylmethyl) furan-3 - il] methoxy] phenyl] - 1-piperazinyl] phenyl] 2 - dihydro - 4 - 2 - [(S) - 1 - (S) - ethyl - 2 - hydroxypropyl - 1,2,4-triazole 3H] - 3-one; (ii) with a nonionic Surfactant; and III) a diluent.The composition allows the Fatty Compound, which has a very low solubility in water, improve the bioavailability in Mammals, such as humans.
机译:药物组合物,其包含:i)抗酵母剂,其为(-)-(2R CIS)-4-[4-[[4-[[5-(2,4-二氟苯基)-5-(1H-trahidro- 1.2.4-三唑1-甲基)呋喃-3-[il]甲氧基]苯基]-1-哌嗪基]苯基] 2-二氢-4-2-[(S)-1-(S)-乙基-2-羟丙基-1,2,4-三唑3H]-3-one; (ii)与非离子表面活性剂;该组合物使脂肪化合物在水中的溶解度非常低,从而提高了哺乳动物(例如人类)的生物利用度。

著录项

  • 公开/公告号TR9802424T2

    专利类型

  • 公开/公告日1999-03-22

    原文格式PDF

  • 申请/专利权人 SCHERING CORPORATION;

    申请/专利号TR19980002424T

  • 申请日1997-05-21

  • 分类号A61K9/48;A61K9/20;A61K47/10;A61K31/495;

  • 国家 TR

  • 入库时间 2022-08-22 02:26:05

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