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3- AND / OR 4-SUBSTITUTED CHINIC ACID DERIVATIVES AND METHOD FOR PRODUCING 3- AND / OR 4-SUBSTITUTED CHINIC ACID DERIVATIVES

机译:3-和/或4-取代的鸟苷酸衍生物和制备3-和/或4-取代的鸟苷酸衍生物的方法

摘要

3- or 4-Mono-, 1,3- or 1,4- or alternatively 3,4-disubstituted derivatives of quinic acid are prepared by reacting a derivative of a hydroxycinnamic acid, in which the phenol group(s) is(are) protected, with a quinic acid derivative so as to form an ester, taking advantage of the different reactivities of the OH functional groups in the 3 and 4 positions in order to carry out the esterification selectively under low temperature conditions, and then the protective groups are cleaved under controlled acidity and temperature conditions. These conditions prevent any degradation or isomerisation. The process makes possible the preparation of new quinides with a good yield.
机译:通过使羟基肉桂酸的衍生物反应制备奎宁酸的3-或4-单-,1,3-或1,4-或3,4-二取代的衍生物,其中的酚基是)用奎宁酸衍生物保护以形成酯,利用3和4位的OH官能团的不同反应性,以便在低温条件下选择性地进行酯化反应,然后保护基团在受控的酸度和温度条件下裂解。这些条件防止了任何降解或异构化。该方法使得可以以高收率制备新的奎尼丁。

著录项

  • 公开/公告号AT177092T

    专利类型

  • 公开/公告日1999-03-15

    原文格式PDF

  • 申请/专利权人 SOCIETE DES PRODUITS NESTLE S.A.;

    申请/专利号AT19920113190T

  • 发明设计人 HUYNH-BA TUONG;

    申请日1992-08-03

  • 分类号C07D307/00;C07C67/29;

  • 国家 AT

  • 入库时间 2022-08-22 02:24:55

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