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3- AND / OR 4-SUBSTITUTED CHINIC ACID DERIVATIVES AND METHOD FOR PRODUCING 3- AND / OR 4-SUBSTITUTED CHINIC ACID DERIVATIVES
3- AND / OR 4-SUBSTITUTED CHINIC ACID DERIVATIVES AND METHOD FOR PRODUCING 3- AND / OR 4-SUBSTITUTED CHINIC ACID DERIVATIVES
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机译:3-和/或4-取代的鸟苷酸衍生物和制备3-和/或4-取代的鸟苷酸衍生物的方法
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摘要
3- or 4-Mono-, 1,3- or 1,4- or alternatively 3,4-disubstituted derivatives of quinic acid are prepared by reacting a derivative of a hydroxycinnamic acid, in which the phenol group(s) is(are) protected, with a quinic acid derivative so as to form an ester, taking advantage of the different reactivities of the OH functional groups in the 3 and 4 positions in order to carry out the esterification selectively under low temperature conditions, and then the protective groups are cleaved under controlled acidity and temperature conditions. These conditions prevent any degradation or isomerisation. The process makes possible the preparation of new quinides with a good yield.
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