ANTISENSE OLIGONUCLEOTIDES TO C-MYB PROTO-ONCOGENE AND USES THEREOF

摘要

Oligonucleotides are provided having a nucleotidesequence complementary to at least a portion of the mRNAtranscript of the human c-myb gene. These "antisense"oligonucleotides are hybridizable to the c-myb mRNAtranscript. Such oligonucleotides are useful in treatinghematologic neoplasms and in inducing immunosuppression.They are particularly useful as bone marrow purgingagents.