Expression of the C-myb Proto-Oncogene during Cellular Proliferation

摘要

In several cell types, messenger RNA levels of the nuclear proto-oncogene c-myb vary as a function of cellular proliferation; a transient increase in c-myb steady-state mRNA, mediated by post-transcriptional mechanisms, occurs during cell-cycle progression. In contrast, both quiescent and proliferating immature thymocytes contain exceptionally high levels of c-myb mRNA as a consequence of increased c-myb transcription. Keywords: Growth physiology; Reprints; Growth factors; Genetics. (kt)