THERMODYNAMICALLY STABLE FORM OF (R)-3- (4-FLUOROPHENYL) SULPHONYLAMINO -1,2,3,4- TETRAHYDRO -9H-CARBAZOLE -9-PROPANOIC ACID (RAMATROBAN)

摘要

The present invention relates to a thermodynamically stable modification ofthe active compound ramatroban of formula (I). The thermodynamically stableform is prepared either by melting of the metastable form and subsequentrecrystallization or by seeding a solution of the metastable active compoundwith a seed crystal of the thermodynamically stable form. Thethermodynamically stable active compound can be employed as an asthma agent.