Mpl-receptor ligands, process for their preparation, medicaments containing themand their use for the treatment and prevention of thrombocytopaenia and anaemia

摘要

The present invention is directed to the use of metal complexes of general formula (I) with Schiff base ligands, which contain sulfur, nitrogen and oxygen as donor atoms, have both an agonistic and synergistic effect on the TPO receptor, in the treatment of diseases or disorders where thrombopoietin or another peptide/protein binding to the mp1 receptor is used as therapeutic agent, particularly in the treatment of thrombopenias and anemias, and drugs containing same, wherein L, X, Me, Y, Z, R, T, and R1 have the above-specified meanings.