METHOD AND COMPOSITION FOR AMELIORATING TISSUE DAMAGE DUE TO ISCHEMIA AND REPERFUSION

摘要

The present invention provides a method for inhibiting tissue damage in warm blooded animals involved in reperfusion of tissue after an extended ischemic period. This method includes treatment with an effective amount of monophosphoryl lipid A or 3-deacylated monophosphoryl lipid A up to 6 hours after a planned ischemic event or after an unplanned ischemic event. Pharmaceutical compositions for treatment are also disclosed.