ANTIGEN PRESENTING CAPSID WITH FUSION MS2 COAT PROTEIN

摘要

The present invention relates to a chimeric protein, which protein is suitable for integration into a vaccine and can form part of a capsid assembly, wherein the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, Or a fragment or variant of said sequence sufficient to retain capsid-forming ability, wherein said amino acid sequence is directed to an epitope by a region corresponding to the container protein hairpin structure of the capsid assembly, as seen in the crystal structure of the free phage. It was modified by inserting.